Glutamine can enhance synaptic transmission in hippocampal slices |
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Authors: | Steven J. Schiff John C. Szerb George G. Somjen |
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Affiliation: | 1. Department of Social Medicine, School of Medicine, Asahikawa Medical University, Japan;2. Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka;3. Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka |
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Abstract: | Activity of 40 single antidromically identified supraoptic neurons was recorded and evaluated in response to a combination of tactile, vulvar massage, vaginal distension, and slow intrajugular 1.2 M sodium chloride infusion in unanesthetized, randomly hydrated ewes. Estradiol-implanted Southdown ewes were prepared according to techniques described by Jennings et al. Only 4 spontaneous firing patterns were observed in the supraoptic nuclei. Analysis of evoked activity indicated that each stimulus evoked alterations in mean firing rates or increased numbers of short interspike intervals in some cells. The resultant activity of units to sequential vulvar massage and 1.2 M sodium chloride infusion suggests a possibility of separate mechanisms of release of oxytocin and vasopressin. |
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Keywords: | glutamine glutamate synaptic transmission hippocampal slice hypoxia |
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