Variation in plasma morphine level and pain sensitivity in prenatally morphinized rats |
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| Authors: | N. G. Chobanov T. A. Voronina S. S. Boiko V. P. Zherdev |
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| Affiliation: | (1) Laboratory of Psychopharmacology and Laboratory of Pharmacokinetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is established that mature random-bred and Wistar rats exhibit the same level of pain sensitivity in the tail-flick test, but the analgetic effect of morphine (5 mg/kg) is variously expressed: marked hypalgesia is observed in mongrel but not in Wistar rats. Prenatal morphinization enhances the analgetic effect of morphine in both mongrel and Wistar rats. There is a direct correlation between the plasma morphine content in prenatally morphinized rats and their sensitivity to the analgetic action of morphine. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N o 9, pp. 273–275, September, 1995 Presented by D. A. Kharkevich, Member of the Russian Academy of Medical Sciences |
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| Keywords: | morphine prenatal period offspring pain sensitivity |
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