| 环氧化酶-2及p53在非小细胞肺癌中的表达与临床意义 |
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| 引用本文： | 张学德,杨锡贵. 环氧化酶-2及p53在非小细胞肺癌中的表达与临床意义[J]. 国外医学(肿瘤学分册), 2007, 0(3) |
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| 作者姓名： | 张学德 杨锡贵 |
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| 作者单位： | 山东省肿瘤医院内二科章丘市人民医院肿瘤科，山东省肿瘤医院内二科章丘市人民医院肿瘤科 |
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| 摘 要： | 研究表明肺癌发生、发展是多种癌基因和抑癌基因相互作用的结果。目前认为环氧合酶- 2(COX-2)参与肺癌的发生、发展、转移等多方面。p53基因是最重要的抑癌基因之一,p53缺失突变与肺癌的发生、发展有关。p53突变与COX-2在非小细胞肺癌(NSCLC)的发生、发展中可能具有协同作用。
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| 关 键 词： | 癌 非小细胞肺 p53 环氧合酶-2 |
Expression of COX-2 and p53 and their clinical implication in non-small cell lung cancer |
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| ZHANG Xuede. Expression of COX-2 and p53 and their clinical implication in non-small cell lung cancer[J]. Foreign Medical Sciences (Cancer Section), 2007, 0(3) |
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| Authors: | ZHANG Xuede |
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| Affiliation: | ZHANG Xuede. the Second Department of Internal Medicine,Shangdong Tumor Hospital,Jinan 250117,China |
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| Abstract: | Studies find oncogenes and suppressor genes are related to genesis and development of lung cancer.COX-2 is related with non-small cell lung cancer(NSCLC)carcinogenesis,progress and meatasta- sis.p53 is the most important tumor suppressor gene.p53 mutation and loss are related to genesis and develop- ment of lung cancer.The cooperation of COX-2 and p53 may play cooperative role in carcinogenesis and pro- gression in non-small cell lung cancer. |
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| Keywords: | Carcinoma non-small-cell lung p53 Cyclooxygenase-2 |
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