雌激素对实验性骨质疏松症骨折愈合的影响

目的 研究不同剂量的雌激素对卵巢除后发生骨质疏检习股骨骨折愈合的影响。方法 成年ｂａｌｂ／ｃ小鼠卵巢除后３个月开始制作右股骨中段闭合骨折模型，同一天开始皮下注射高低两种剂量雌激素，小鼠于折骨后５、１０、１５、２０、３０天分批处死，采用Ｘ射线、骨痂称重、骨痂中钙盐沉积率测定、组织学检查、血清生化检测等方法研究雌激素对骨折愈合的影响，并和卵巢除组、假手术对照组进行比较。结果 卵巢除组骨痂较小，

Effects of estrogen on fracture healing of experimental osteoporotic mice

Objective　To investigate the effects of estrogen on fracture healing of ovariectomized mice with serious bone loss. Methods　Adult balb/c mice underwent fracture of right femurs at middle point three months after ovariectomy and began to receive low and high doses of estrogen.Animals were sacrificed at 5,10,15,20 and 30 days after fracture.X-rays,callus weighing,calcium depositing rate measurement,histological study and serun biochemical examination were used to investigate the effects of estrogen on fracture healing,and to compare with ovariectomized (OVX)group and sham-operated control(SO) group. Results　The calluses were small in OVX group,but the callus maturity was not affected.High dose of estrogen impaired cartilage callus calcification while low dose of estrogen affected callus formation little. Conclusion　Estrogen deficiency and super-physiological level of estrogen both interfere with fracture healing of ovarietomized mice.Physiological level of estrogen interferes with fracture healing little in ovariectomized mice.