壳聚糖导管材料的制备及力学性能研究

目的壳聚糖在组织工程血管支架、神经修复导管等方面虽有潜在的广泛用途,但体内降解慢,本实验研究壳聚糖导管在满足基本力学性能要求下尽量降低管壁的厚度,以缩短降解时间。方法在初始溶液中加入聚乙二醇、甘油,通过浸渍-沥滤法制备壳聚糖管状材料,研究不同的成型工艺参数对壳聚糖导管力学性能的影响。结果在初始溶液中加入适量的甘油有利于提高壳聚糖导管的断裂应力和断裂伸长率,但其杨氏模量无显著变化;2%的壳聚糖初始溶液较2.5%所制备的导管的断裂应力、断裂应变和杨氏模量高;制备过程浸入-干燥的次数为2次的较3次制备出的导管的断裂应力、断裂应变和杨氏模量高。结论初始溶液中甘油、壳聚糖浓度以及重复次数都会影响导管的力学性能,优化成型工艺能在满足基本力学性能要求下降低管壁的厚度以达到最佳效果。

Study on fabrication and mechanical property of chitosan conduit

Objective Chitosan has a potential use in tissue engineered blood vessel and nerve regeneration conduit, but it degrades slowly.This research aims at minishing the chitosan conduit wall thickness with its fundamental mechanical property remained so as to shorten its degradation time.Methods Chitosan conduits were manufactured by adding some glycerol and PEG to the original solution and then using immersing-filtering methods.Effects of different molding parameters on chitosan conduit mechanical property were studied.Results Adding appropriate glycerol to original solution was of benefit to improve chitosan conduit's broken stress and broken elongation, but having no apparent effect on its Yang's modulus;the conduit's broken stress, broken elongation and Yang's modulus made of 2% chitosan were higher than that of 2.5% chitosan;with twice immersion-dryness, the conduit's broken stress, broken elongation and Yang's modulus were higher than that of thrice.Conclusion Chitosan conduit's mechanical property could be influenced by the original glycerol, the chitosan content and repeat times, and the best conduit wall thickness could be achieved by optimizing molding parameters.