冠状动脉支架置入术后多形核白细胞活化的相关分子的表达

目的:探讨冠状动脉支架置入术后多形核白细胞(PMN)活化的相关分子的表达。方法:选择18例不稳定型心绞痛患者,在冠状动脉支架置入前(T0)和置入后30 min、3 h、6 h、12 h、24 h(分别为T1~T5)用ELISA法测定血白细胞介素-8(IL-8)、髓过氧化物酶(MPO)、L-选择素(L-selectin)、超敏C反应蛋白(hs-CRP)浓度。结果:支架组T1~T5各时段的PMN相关分子IL-8、MPO、L-selectin、hs-CRP表达增加,它们分别在支架置入后3 h、30 min、12 h、24 h达高峰,同T0比较差异有统计学意义(P<0.01)。结论:冠状动脉支架置入术后IL-、MPO、L-selectin、hs-CRP表达增加,触发PMN的聚集和局部的炎症反应。

Polymorphonuclear neutrophil markers of activation after percutaneous coronary stenting in patients with unstable angina

Objective:The aim of the study was to determine the presense of Polymorphyonuclear neutrophils(PMN)activation after coronary stenting in patients with unstable angina.Method:Plasma levels of IL-8,myeloperoxidase(MPO),high-sensitivity C-reactive protein(hs-CRP) and L-selectin were assayed in 18 patients undergoing percutaneous coronary stenting(group A)and compared with 7 patients undergoing coronay angiography only(group B).Serial sampling starting before stenting and continued for 24 h was carried out in all patients.Result:A significant elevation in IL-8,MPO,L-selectin,hs-CRP were observed after stenting in 3 h,30 min,12 h,24 h(P<0.01).Conclusion:Coronary stenting is associated with an immediate polymorphonuclear neutrophils activation followed by release of inflammtory cytokine.