Clinicopathological variables associated with lymph node metastasis in submucosal invasive gastric cancer |
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Authors: | Shinji Ohashi Shozo Okamura Fumihiro Urano Matsuyoshi Maeda |
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Institution: | (1) Center for Preventive Medicine, Toyohashi Municipal Hospital, 50 Aotake-cho, Toyohashi 441-8085, Japan;(2) Department of Gastroenterology, Toyohashi Municipal Hospital, Toyohashi, Japan;(3) Department of Pathology, Toyohashi Municipal Hospital, Toyohashi, Japan |
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Abstract: | Background We aimed to elucidate clinicopathological variables associated with lymph node metastasis of submucosal invasive gastric cancer.
Methods Specimens were surgically resected from 201 patients who had primary submucosal gastric cancer. We studied 39 consecutive
patients with lymph node metastasis and 162 patients without lymph node metastasis. We compared the following clinicopathological
characteristics of the patients in relation to lymph node metastasis: age, sex, tumor size, histology, extent of submucosal
invasion, lymphatic and venous invasion, and ulceration of the tumor. Submucosal invasion was divided subjectively into sm1,
sm2, and sm3 (representing invasion of the upper-, middle-, and lower-third of the submucosa, respectively). We also studied
the relationship between lymph node metastasis of submucosal gastric cancer and immunohistochemistry for p53, Ki67, vascular
endothelial growth factor (VEGF), α-fetoprotein, sLea, and dendritic cells (DCs).
Results In terms of conventional pathological factors, lymph node metastasis in submucosal gastric cancer was related to tumor size
(P = 0.002), depth of submucosal invasion (P = 0.001), lymphatic invasion (P < 0.0001), and venous invasion (P = 0.012). Lymph node metastasis in sm1 gastric cancer was significantly related to VEGF expression (P = 0.047). Also, lymph node metastasis in sm3 gastric cancer was significantly correlated with DC expression (P = 0.016). Multivariate analysis showed that tumor size, tumor invasion depth in the submucosal layer, and lymphatic invasion
were independent predictors of nodal metastasis in submucosal gastric cancer.
Conclusion Conventional pathological factors, such as tumor size, depth of submucosal invasion, and lymphatic invasion, have a significant
influence on lymph node metastasis. VEGF expression and DC expression may be helpful predictors of lymph node metastasis in
patients with sm1 and sm3 gastric cancer, respectively. |
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Keywords: | DC Lymph node metastasis Submucosal gastric cancer VEGF |
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