| 大豆皂甙的抑瘤效应 |
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| 引用本文： | 郁利平,赵清池,刘及,江曼涛.大豆皂甙的抑瘤效应[J].吉林大学学报(医学版),1992(4). |
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| 作者姓名： | 郁利平 赵清池 刘及 江曼涛 |
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| 作者单位： | 白求恩医科大学食品卫生教研室
(郁利平，赵清池，刘及)，白求恩医科大学新药研究室(江曼涛) |
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| 摘 要： | 本实验通过大豆皂甙Total soyasaponin TS]对肿瘤细胞的间接作用和直接作用,研究TS的抑瘤效应。体内实验结果表明:经口投予TS的S180荷瘤鼠,其TS可间接作用S180细胞而抑制它的生长;将TS经腹腔注射使TS直接作用于S180腹水瘤细胞,TS也非常明显地抑制肿瘤细胞的生长。体外实验结果亦证明TS可直接杀伤肿瘤细胞,即TS可明显地抑制S180细胞和YAC-1细胞的DNA合成,并对K562细胞和YAC-1细胞有明显的细胞毒作用。
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| 关 键 词： | 大豆皂甙 荷瘤 S180细胞 NK活性 |
INHIBITING EFFECT OF TOTAL SOYASAPONIN ON TUMOR CELLS |
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| Yu Liping,Jiang Mantao,Zhao Qingchi.INHIBITING EFFECT OF TOTAL SOYASAPONIN ON TUMOR CELLS[J].Journal of Jilin University: Med Ed,1992(4). |
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| Authors: | Yu Liping Jiang Mantao Zhao Qingchi |
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| Abstract: | Direct and indirect inhibitory effect of total soyasapanin (TS) on tumor cells was studied. In vivo, when TS was given by mouth or i. p., growth of S180 cells was inhibited directly in晅umor-bearing mice. In vitro, it was also identified that TS may kill the tumour cells directly through inhibition of DNA synthesis in S180 cells and YAC-1 cells. Moreover, it also exerted a marked cyto-toxic action on K562 cells and YAC-1 cells. |
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| Keywords: | Total soyasaponin Transplanted tumors S180 cells NK activity |
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