血管活性药物及中药麝香对内毒素性休克的影响及其在抗休克治疗中的作用

目的 :观察缩、扩血管西药及中药麝香对低排高阻型内毒素性休克的影响 ,评价其在抗休克治疗中的疗效。方法 :大鼠随机分为对照组 (A组 )、山莨菪碱组 (B组 )、去甲肾上腺素组 (C组 )、麝香组 (D组 )。颈外静脉推注脂多糖 (LPS)复制内毒素休克模型 ,实验组分别给予山莨菪碱、去甲肾上腺素、麝香药物后观察肠系膜微循环、血压变化。结果 :推注LPS后对照组及实验组动物均发生内毒素性休克 ,出现微循环障碍。山莨菪碱能提高休克后血流速度 ,但A、C、D组微循环未出现明显改善。结论 :山莨菪碱可改善内毒素性休克的微循环瘀滞状态 ,而去甲肾上腺素 ,麝香没有明显作用。

Influence of Vasoactive Drugs and Musk on Ednotoxic Shock and the Effect of Their Anti-Shock

Objective: To observe the effect of vasodilator and vasomotor medicine and Chinese traditional medicine musk on endotoxic shock.Evaluate the curative effects of these drugs in anti-shock therapy.Method: Four groups of normal rats were selected randomly.Group A was control,group B was anisodamine-treat group,group C was noradrenalin-treat group,group D was musk-treat group.Inject lipoplysaccharide into the right external jugular veins to set up endotoxic shock models.Anisodamine,noradrenalin and musk was injected into experiment groups respectively,then observed the changes of microcirculations of mesentery and blood pressure.Results: Four groups developed shock after injected LPS.Giving anisodamine can accelerate the blood flow,improve the stagnant condition of the microcirculation.Giving noradrenalin or musk has no significant effect on microcirculation.Conclusion: Anisodamine can improve the stagnant condition of the microcirculation,but noradrenalin and musk can not.