髂内动脉术中化疗辅助治疗宫颈癌的临床分析

背景与目的:探讨在宫颈癌根治术中髂内动脉灌注化疗的疗效。材料与方法:回顾性分析1996-01～2003-01、7年间105例行宫颈癌根治术,并于术中进行双侧髂内动脉灌注化疗患者的临床资料(化疗组),并与同期50例根治术中未行灌注化疗患者(对照组)进行比较,比较两组患者术后近期临床疗效、术后复发情况、复发率及生存率情况。结果:化疗组于术后3年内3例盆腔复发,2例远处转移,转移复发率为4.81%;对照组中7例于术后3年半内盆腔复发,1例远处转移,转移复发率为18.00%。对照组复发转移率高于化疗组。2年生存率:化疗组为95.0354%,对照组为83.6237%,前者高于后者;4年生存率:化疗组为95.0354%,对照组为79.4833%,前者高于后者。结论:宫颈癌根治术中选择髂内动脉灌注化疗,可降低宫颈癌根治术后复发转移率及死亡率,有效提高患者生存率。

Retrospective Analysis of Internal Iliac Arterial Infusion Chemotherapy in Radical Surgery for The treatment of Cervical Cancer

BACKGROUND&AIM: To explore the clinical therapeutic effect of intraoperative internal iliac arterial chemotherapy in the course of radical surgery of cervical cancer. MATERIAL AND METHODS: To retrospectively analyse the clinical data of105patients with cervical cancer,who received a radical surgery of cervical cancer and were also administered Cisplatin(DDP)via the internal iliac artery during the operation(DDP group).A nonrandomized control group of50patients who were not administered DDP intraoperatively was used for comparison(control group).Their therapeutic effect in the near future,recurrence of postoperation and the result of follow-up(including the survival rate and recurrence rate)were analyzed and compared. RESULTS: The recurrence rate of DDP group was4.81%and5cases recurred diversion(3cases pelvic cavity diversion,2cases distant diversion)within3years` follow-up and the recurrence rate of control group was18.00%,and8cases recurred diversion(7cases pelvic cavity diversion,1cases distant diversion)within3years'follow-up.The recurrence rate of control group was higher than that of the DDP group( P =0.027).The two years'survival rate in DDP group was95.0354%and in control group was83.6237%,respectively( P =0.047).The four years'survival rate was95.0354%in DDP group and79.4833%in control group( P =0.012). CONCLUSION: Intraoperative bilateral internal iliac arterial infusion chemotherapy in the course of radical surgery of cervical cancer can lower the recurrence rate the and effectively raise the survival rate.