Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice |
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Authors: | Powrie Fiona; Leach Michael W; Mauze Smita; Caddie Linda Barcomb; Coffman Robert L |
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Institution: | DNAX Research Institute of Molecular and Cellular Biology Inc. 901 California Ave., Palo Alto, CA 94040, USA
1 Schering-Plough Research Institute PO Box 32, Route 94, Lafayette, NJ 07848, USA |
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Abstract: | CD4+ T cells in the mouse can be subdivided into two fractionsbased on the level of expression of the CD45RB determinant.Previous studies have shown that these subsets are functionallydistinct. We have further characterized the properties of thesesubpopulations in vivo by injecting them into C. B-17 scid mice.The animals restored with the CD45RBhighCD4+ T cell populationdeveloped a lethal wasting disease with severe mononuclear cellinfiltrates into the colon and elevated levels of IFN- mRNA.In contrast, animals restored with the reciprocal CD45RBlowsubset or with unfractionated CD4+ T cells did not develop thewasting or colitis. Importantly, the co-transfer of the CD45RBlowpopulation with the CD45RBhigh population prevented the wastingdisease and colitis. These data indicate that important regulatoryinteractions occur between the CD45RBhigh and CD45RBlowCD4+T cell subsets and that disruption of this mechanism has fatalconsequences. |
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Keywords: | CD45 CD4+ T cell subsets colitis immunoregulation inflammation |
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