| 脑缺血后脑组织NO含量和NOS活性变化及三七总皂甙的影响 |
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| 引用本文： | 许长庆,夏作理,史义菊,钱采韵. 脑缺血后脑组织NO含量和NOS活性变化及三七总皂甙的影响[J]. 中国神经精神疾病杂志, 1997, 0(2) |
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| 作者姓名： | 许长庆 夏作理 史义菊 钱采韵 |
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| 作者单位： | 中山医科大学附一院神经科，泰山医学院附院老年病科，泰山医学院附院老年病科，中山医科大学附一院神经科 博士生，510080原泰山医学院附属医院老年病科 |
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| 摘 要： | 为了探讨一氧化氮 (NO)在缺血神经元坏死中的作用机制及三七总皂甙 (PNS)是否通过影响NO的变化而起脑保护作用。 方法 用栓线法建立大鼠局灶性脑缺血模型 ,测定脑缺血后不同时间脑组织NO含量和一氧化氮合成酶 (NOS)活性变化及PNS对其的影响。 结果 缺血后 3 0分钟脑组织NO含量和NOS活性均显著升高 (P <0 0 1 ) ,而PNS能防止脑缺血后两者的升高。NO含量与NOS活性呈显著正相关。 结论 NO在缺血神经元损伤中起重要作用 ,PNS是通过降低NO的含量而起保护脑组织作用
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| 关 键 词： | 脑缺血 一氧化氮 一氧化氮合成酶 三七总皂甙 |
The effect of PNS on the alterations of NO content and NOS activity in brain tissues following MCAO in rats. |
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| Xu Changqing,Xia Zuoli,Shi Yiju,et al.. The effect of PNS on the alterations of NO content and NOS activity in brain tissues following MCAO in rats.[J]. Chinese Journal of Nervous and Mental Diseases, 1997, 0(2) |
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| Authors: | Xu Changqing Xia Zuoli Shi Yiju et al. |
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| Abstract: | Objective To explore the mechanism of nitric oxide (NO) in ischemic neuronal death and observe whether the protection of ischemic neuronal tissue by panax notoginseng saponins (PNS) was by influencing on NO production or not. Methods The model of right middle cerebral artery oclusion (MCAO) focal cerebral ischemia in rats was established by inserting thread method and the changes of NO concentrations and nitric oxide synthase (NOS) activity in brain tissues were measured and effect of PNS on them was observed. Results The content of NO and activity of NOS significantly increased at 30 min after MCAO. PNS cacld inhibit their increases. There was a significant positive correlation between NO content and NOS activity. Conclusions NO may play an important role in ischemic neuronal damage and PNS can protect against cerebral ischemic neuronal death by decreasing the production of NO. |
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| Keywords: | Cerebral ischemia Nitric oxide NOS PNS |
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