| 胰岛素对淋巴细胞免疫活性的调节作用 |
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| 引用本文： | 曲迅. 胰岛素对淋巴细胞免疫活性的调节作用[J]. 中国药理学通报, 1992, 2(2): 139-142 |
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| 作者姓名： | 曲迅 |
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| 作者单位： | 山东省医科院基础所免疫室，山东省医科院基础所免疫室，山东省医科院基础所免疫室，山东省医科院基础所免疫室，泰山医学院药理教研室 济南250001 泰山医学院微生物室 271000，济南250001，济南250001，济南250001，山东271000 |
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| 摘 要： | 以四氧嘧啶糖尿病小鼠为模型,观测模型鼠免疫细胞活性及胰岛素对其脾淋巴细胞DNA合成及白细胞介素2(IL-2)产生的影响。实验结果表明,病鼠在高血糖低胰岛素状态下淋巴细胞DNA合成及IL—2的产生均明显降低(均P<0.01)。将病鼠脾淋巴细胞悬浮于含胰岛素的培液内,其淋巴细胞DNA合成及IL-2产生均显著升高。
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| 关 键 词： | 胰岛素 糖尿病 淋巴细胞 白细胞介素2 |
THE REGULATION EFFECTS OF INSULIN ON THE LYMPHOCYTES IN MICE |
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| Qu Xun,Cui Zhengyan,Li Shuzhen. THE REGULATION EFFECTS OF INSULIN ON THE LYMPHOCYTES IN MICE[J]. Chinese Pharmacological Bulletin, 1992, 2(2): 139-142 |
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| Authors: | Qu Xun Cui Zhengyan Li Shuzhen |
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| Abstract: | The in vitro modulation effect of insulin on DNA and IL-2 production of spleen lymphocytes in diabetic mice were studied. The results suggest that the DNA and IL-2 production of the lymphoc-ytes are significantly inhibited in the mice. When suspend the lymphocytes to the culture medium containing insulin, the DNA and IL -2 production of the lymphocytes are remarkably increased. Therefore, insulin is an important immunoregulation hormone. |
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| Keywords: | Insulin Diabetes Lymphocyte Interleukin 2 (IL-2) |
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