鲁南地区煤矿工人血清25-OH-D水平检测及相关因素分析

目的对鲁南地区煤矿工人维生素D营养状况进行综合评价,为其健康宣教提供依据。方法以鲁南地区290例从事井下工作10 a以上的男性煤矿职工（观察组）及60例同期健康查体者（对照组）为研究对象,均抽取清晨空腹静脉血,用酶联免疫定量法检测血清25-羟基维生素D（25-OH-D）水平,并以Spearman等级相关法分析其相关性。结果观察组和对照组血清25-OH-D水平分别为（44.64±32.65）、（51.21±21.59）nmol/L（P〈0.05）,观察组并2型糖尿病（T2DM）和非T2DM者分别为（39.95±20.33）、（44.57±31.72）nmol/L,T2DM者显著低于非T2DM者和对照组（P均〈0.05）;观察组血清25-OH-D水平与年龄、工龄及是否伴有T2DM等有关,但与吸烟、饮酒及骨折史等无明显相关性。结论鲁南地区煤矿工人血清维生素D水平偏低,尤以年龄大、工龄长及伴T2DM者为著;此类人群应注重多参加户外活动,接受适当日光照射,并适量补充维生素D。

Measurement of serum 25-hydroxy vitamin D of coal miners in the south of Shandong province and analysis of the related factors

Objective To evaluate the vitamin D nutritional status of coal miners in the south of Shandong province,and provide the basis for their health education.Methods Choose 290 male miners in the south of Shandong province who have been engaged in underwork operations for more than ten years（observed group） and 60 healthy controls（control group） as study subjects,venous fasting blood of the two groups were collected,the serum 25-OH-D levels were detected using quantitative enzyme-linked immunosorbent assay,and the related factors were analyzed by Spearman rank correlation method.Results The serum 25-OH-D levels of the observed group and control group were（44.64±32.65）and（51.21±21.59）nmol/L（P0.05） respectively,which of the T2DM and non-T2DM in the observed group were（39.95±20.33） and（44.57 ± 31.72） nmol/L respectively,serum 25-OH-D of the T2DM were significantly lower than that of the non-T2DM and the control group（all P0.05）,the serum 25-OH-D level in observed group is associated with age,length of service and whether with T2DM,but was not related significantly with smoking,drinking and the history of fractures.Conclusion The Serum 25-OH-D level of underground miners in the south of Shandong province is relative low,particularly in cases of older,long years of service and T2DM;such people should take part in outdoor activities,receive proper sunlight,and complement vitamin D.