| 他汀对未合并冠心病的高胆固醇血症患者血管内皮功能的影响 |
| |
| 引用本文： | 张素敏,王广,曾辉,刘金波,于婕,米琳,毛节明.他汀对未合并冠心病的高胆固醇血症患者血管内皮功能的影响[J].山东医药,2010,50(36):7-9. |
| |
| 作者姓名： | 张素敏 王广 曾辉 刘金波 于婕 米琳 毛节明 |
| |
| 作者单位： | 北京大学第三医院,北京,100191 |
| |
| 基金项目： | 国家自然科学基金，中华医学会临床医学科研专项资金资助项目，北京大学第三医院中青年骨干基金 |
| |
| 摘 要： | 目的探讨辛伐他汀对未合并冠心病的高胆固醇血症患者血管内皮功能及动脉僵硬度的影响。方法 30例高胆固醇血症患者应用辛伐他汀20 mg/d治疗12周,治疗前后分别采集空腹静脉血,通过酶联免疫吸附实验检测血浆一氧化氮（NO）水平;应用动脉硬化测定仪测定肱踝脉搏波传导速度（PWV）,评价动脉硬化程度;应用彩色多普勒超声诊断仪测定肱动脉血流速度积分（VTI）,评价血管舒张功能。结果辛伐他汀治疗后患者总胆固醇（TC）、低密度脂蛋白胆固醇水平明显降低,PWV水平显著降低,血浆NO、肱动脉VTI值显著高于基线水平。结论辛伐他汀可改善无明确冠心病的高脂血症患者血管内皮功能及动脉硬化程度。
|
| 关 键 词： | 辛伐他汀 高胆固醇血症 冠状动脉疾病 内皮功能 |
Effects of simvastatin on the endothelial function in hyperlipidemia patients without coronary artery disease |
| |
| ZHANG Su-min,WANG Guang,ZENG Hui,LIU Jin-bo,YU Jie,MI Lin,MAO Jie-ming.Effects of simvastatin on the endothelial function in hyperlipidemia patients without coronary artery disease[J].Shandong Medical Journal,2010,50(36):7-9. |
| |
| Authors: | ZHANG Su-min WANG Guang ZENG Hui LIU Jin-bo YU Jie MI Lin MAO Jie-ming |
| |
| Institution: | ZHANG Su-min,WANG Guang,ZENG Hui,LIU Jin-bo,YU Jie,MI Lin,MAO Jie-ming(Peking University Third Hospital,Beijing 100191,P.R.China) |
| |
| Abstract: | Objective To investigate the effects of simvastatin on vascular endothelium function in hyperlipidemia patients without coronary artery disease.Methods Thirty hyperlipidemia patients were treated with simvastatin(20 mg/d)for 12 weeks.Lipid profile was conducted through venenblut translating while fasting in the morning before and after therapy.The plasma was collected before and after simvastatin treatment.NO was detected through enzyme-linked immunosorbent reaction.Atherosclerosis tester was used to detect... |
| |
| Keywords: | simvastatin hypercholesterolemia coronary disease endothelial function |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
