|
|||||
|
|
| 不同严重度COPD患者血清MMP-9、TIMP-1浓度变化及相关性研究 | |
| 引用本文： | 李蕾,林松娟,冯海霞,邹志伟.不同严重度COPD患者血清MMP-9、TIMP-1浓度变化及相关性研究[J].现代医药卫生,2011,27(9):1289-1290. |
| 作者姓名： | 李蕾 林松娟 冯海霞 邹志伟 |
| 作者单位： | 1. 山东潍坊医学院内科学教研室,山东潍坊,261042 2. 山东潍坊医学院附属医院,山东潍坊,261000 3. 山东临沂姚店子镇医院,山东,临沂,276400 |
| 摘 要： | 目的:探讨不同严重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清MMP-9、TIMP-1的浓度变化及相关性.方法:用酶联免疫吸附法(ELISA)测定53例不同病情分度的COPD患者(轻度11例、中度16例、重度14例、极重度12例)血清MMP-9、TIMP-1的浓度(ng/ml).结果:与轻度(52.46±10.59;161.63±7.26)COPD患者相比,中度(111.73±25.40;201.73±19.27)、重度(188.41±20.72;257.05±13.97)、极重度(236.31±10.93;313.07±15.97)患者血清MMP-9、TIMP-1浓度显著升高.与中度COPD患者相比,重度、极重度患者血清MMP-9、TIMP-1浓度显著升高;与重度COPD患者相比,极重度患者血清MMP-9、TIMP-1浓度显著升高,P均<0.05;不同COPD病情严重度与MMP-9、TIMP-1、MMP-9/TIMP-1均呈正相关,相关系数分别为0.791,0.782,0.766,P<0.01.结论:随着COPD患者病情严霞程度的加重,血清MMP-9、TIMP-1的浓度及MMP-9/MMP-1比率升高,并且与气流阻塞(用ICEV1/FVC%及FEV1%预计值表示)成负相关,可以作为评价患者病情严重程度的指标,也可初步预测治疗效果. |
| 关 键 词： | 不同严重度 慢性阻塞性肺疾病 组织基质会属蛋白酶-9 基质金属蛋白酶抑制剂-1 |
Concentration changes of serum MMP-9 and TIMP-1 and their relativity with different disease severities in COPD patients |
|
| LI Lei , LIN Song-juan , FENG Hai-xia , ZOU Zhi-wei.Concentration changes of serum MMP-9 and TIMP-1 and their relativity with different disease severities in COPD patients[J].Modern Medicine Health,2011,27(9):1289-1290. | |
| Authors: | LI Lei LIN Song-juan FENG Hai-xia ZOU Zhi-wei |
| Institution: | LI Lei1,LIN Song-juan2,FENG Hai-xia1,ZOU Zhi-wei3(1.Department of Internal Medicine,Weifang Medical University,Weifang,Shandong 261042,China,2.Affiliated Hospital,3.Yaodianzi Town Health Center,Linyi,Shandong 276400,China) |
| Abstract: | Objective:To estimate the serum concentration of matrix metalloproteinase-9(MMP-9),tissue inhibitors of matrix metalloproteinase(TIMP-1) in the patients with chronic obstructive pulmonary disease(COPD) and to evaluate the correlation between MMP-9 and TIMP-1 with the disease severity in COPD.Methods:Fifity-three COPD patients were enrolled(mild 11,moderate 16,severe 14,extreme severe 12).In four groups the spirometry was performed and the serum concentrations were measured using enzyme-linked immunosorbent ... |
| Keywords: | Different disease severities COPD MMP-9 TIMP-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |