Coffee and caffeine intake and risk of endometriosis: a meta-analysis |
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Authors: | Francesca Chiaffarino Francesca Bravi Sonia Cipriani Fabio Parazzini Elena Ricci Paola Viganò Carlo La Vecchia |
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Institution: | 1. Department of Obstetrics, Gynecology and Neonatology, IRCSS Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy 2. IRCCS “Mario Negri” Institute for Pharmacological Research, Milan, Italy 3. Department of Clinical Medicine and Community Health, University of Milan, Milan, Italy 4. Obstetrics and Gynecology Unit, San Raffaele Scientific Institute, Milan, Italy
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Abstract: | Purpose The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue. Methods We performed a meta-analysis of epidemiological studies published up to January 2013. We computed summary relative risks (RR) of endometriosis for any, high and low versus no coffee/caffeine consumption. Results We identified a total eight studies, six case–control and two cohort studies, including a total of 1,407 women with endometriosis. The summary RR for any versus non-consumption were 1.26 95 % confidence interval (CI) 0.95–1.66] for caffeine and 1.13 (95 % CI 0.46–2.76) for coffee consumption; the overall estimate was 1.18 (95 % CI 0.92–1.49). The summary RR were 1.09 (95 % CI 0.84–1.42) and 1.09 (95 % CI 0.89–1.33) for high and low caffeine consumption as compared to no consumption, respectively. Conclusion The present meta-analysis provided no evidence for an association between coffee/caffeine consumption and the risk of endometriosis. Coffee/caffeine consumption, as currently used in diet, does not carry a health risk. |
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