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Hepatitis B virus DNA polymerase activity and hepatitis B e antigen (HBeAg)/anti-HBe status among type B chronic liver diseases |
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| Authors: | Seizaburo Kashiwagi MD Jun Hayashi Hideyuki Ikematsu Hideyuki Nomura Wataru Kajiyama Toshimitu Shingu Kazuo Hayashida Masaro Kaji |
| Affiliation: | 1. First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan 3. Department of Pediatrics, Nichinan Prefectural Hospital, 887, Nichinan, Japan 4. Ohji Central Clinic, Ohji Co., 887, Nichinan, Japan 5. First Department of Internal Medicine, School of Medicine, Kurume University, 830, Kurume, Japan |
| Abstract: | To investigate the relationship between hepatitis B virus (HBV) replication and chronic liver disease, age-specific prevalences of HBeAg, anti-HBe, and HBV DNA polymerase (DNAP) activity were studied in 295 asymptomatic HBV carriers and 183 patients with B-type chronic liver diseases. DNAP activity decreased with age, and there was no difference in the overall prevalence of DNAP activity between the asymptomatic carriers (27.8%) and the chronic liver disease patients (27.3%). The prevalence of DNAP activity in the 40-and-over age group was significantly higher for the chronic liver disease patients (17.5%) than for the asymptomatic carriers (1.7%). The prevalence of HBeAg in the 40- and-over age group was also significantly higher for the chronic liver disease patients (33.8%) than for the asymptomatic carriers (2.6%). These data suggest that viral replication decreased with age and that viral replication occurring in older persons closely related to chronic liver disease. |
| Keywords: | Asymptomatic carriers Chronic liver disease Hepatitis B e antigen/antibody Hepatitis B virus HBV DNA polymerase |
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