长链非编码RNA TUG1在前列腺癌组织中的表达及与预后的关系

目的:探究长链非编码核糖核酸（lncRNA）牛磺酸上调基因1（TUG1）在前列腺癌（PCa）患者癌组织中的表达水平及与预后的关系。方法:以本院收治的54例PCa患者为研究对象，取癌组织和癌旁正常组织，采用qRT-PCR检测lncRNA TUG1表达水平，分析TUG1表达与PCa患者临床病理参数的关系，Kaplan-Meier分析PCa患者生存情况，COX回归分析影响PCa患者预后的危险因素。结果:TUG1在PCa患者癌组织中的表达水平显著高于癌旁正常组织（P＜0.05）；PCa患者癌组织中TUG1表达水平与患者年龄、淋巴结转移情况、T分期、前列腺特异性抗原（PSA）水平和Gleason评分有关（P＜0.05）；Kaplan-Meier法分析结果显示TUG1低表达组PFS、OS均显著高于高表达组（P＜0.05）；COX分析结果显示TUG1表达、PSA水平和Gleason评分是影响PCa患者预后的独立危险因素。结论:lncRNA TUG1在PCa患者癌组织中高表达，与PCa发生及发展有关，可作为临床评估患者预后的参考指标。

The expression of long non-coding RNA TUG1 in prostate cancer tissues and its relationship with prognosis

Objective:To investigate the expression of long non-coding ribonucleic acid(lncRNA)taurine up-regulated gene 1(TUG1)in prostate cancer(PCa)tissues and its relationship with prognosis.Methods:54 cases of PCa in our hospital were selected as the research objects.The cancerous tissues and adjacent normal tissues were taken.The expression level of lncRNA TUG1 was detected by qRT-PCR.The relationship between TUG1 expression with clinicopathological parameters of PCa patients was analyzed.Kaplan-Meier was used to analyze the survival of PCa patients,COX regression analysis was used to analyze the prognostic factors of PCa patients.Results:The expression level of lncRNA TUG1 in cancer tissues of PCa patients was significantly higher than that in adjacent normal tissues(P<0.05).The expression of TUG1 in cancer tissues of PCa patients was correlated with age,lymph node metastasis,T stage,PSA level and Gleason score(P<0.05).Kaplan-Meier analysis showed that PFS and OS in low expression group were significantly higher than those in high expression group(P<0.05).COX analysis showed that TUG1 expression,PSA level and Gleason score were independent risk factors for the prognosis of PCa patients.Conclusion:LncRNA TUG1 is highly expressed in cancer tissues of PCa patients,which is related to the occurrence and development of PCa.It can be used as a reference index for clinical evaluation of prognosis.