Study structure may compromise understanding of longitudinal decision regret stability: A systematic review |
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| Institution: | 1. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, 2522, Australia;2. Department of Clinical Nutrition, Wollongong Hospital, Illawarra Shoalhaven Local Health District, Wollongong, New South Wales, 2500, Australia;1. Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China;2. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China;3. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;1. Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, USA;2. Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA;3. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA;6. The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, UK;7. Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, USA;8. Department of Radiotherapy, Centre Léon Bérard, Lyon, France;9. Department of Urology, University of California, Los Angeles, USA;1. Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;2. Department of Urology, Tan Tock Seng Hospital, Singapore;3. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore—Imperial College London, Singapore;4. Tufts University School of Medicine, Boston, MA, USA;5. Division of Urology, Maine Medical Center, Portland, ME, USA;6. Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME, USA;7. VUI Center for Outcomes Research, Analytics and Evaluation, Henry Ford Health System, Detroit, MI, USA;1. Department of Oncology, University of Turin, at Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy;2. Department of Oncology, University of Turin, at Ordine Mauriziano Hospital, Turin, Italy;3. Department of Oncology, University of Turin, at San Luigi Gonzaga Hospital, Orbassano (TO), Italy;4. Clinical Trials Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale”-IRCCS, Naples, Italy |
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| Abstract: | ObjectivesTo perform a systematic review of decision regret studies in cancer patients to determine if regret is longitudinally stable, and whether these study structures account for late-emerging treatment effects.MethodsOnline databases including the George Mason Libraries, Global Health, Nursing and Allied Health, and PubMed were searched to identify decision regret studies with longitudinal components in patients with cancer.ResultsA total of 845 unique citations were identified; 20 studies met inclusion criteria. Data was also collected on the time horizon for 90 studies; 47 % of studies evaluated regret at time points of one year or less, although this has increased significantly in prostate cancer citations since 2010. Regret was infrequent, affecting less than 20 % of patients, and often stable. Effect sizes in studies where decision regret changed over time were small to negligible.ConclusionLongitudinal effects can influence the expression of decision regret, yet many studies are not designed to collect long-term data; prostate cancer studies may be particularly disadvantaged. The degree of this influence in current studies is small, though this outcome must be interpreted with caution.Practice ImplicationsProviders should be aware of the risk of late-emerging regret and counsel patients appropriately. |
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| Keywords: | Decision regret Study structure Time horizon Cancer |
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