苏州地区不同年龄女性HPV感染的流行病学调查

目的:调查苏州地区女性人乳头瘤病毒（HPV）感染现状和亚型分布情况，为宫颈癌防治政策提供理论依据。方法:2016年7月至2019年3月对苏州地区20~65岁的女性进行随机抽样调查。采用PCR体外扩增和DNA反向点杂交相结合的HPV基因分型检测技术，分析苏州地区HPV的感染状况。结果:在符合条件的4 275名女性中共检出964例HPV阳性者，阳性率为22.55％（964/4275）。其中高危型HPV（HR-HPV）阳性有812例，占HPV感染人群84.23％（812/964）。在检出的23种HPV亚型中，按感染率由高到低排列分别为52、81、16、58、53、51、68、56、42、33、18、66、59、11、43、31、39、6、45、35、82、83、73亚型。不同年龄段HPV感染率不同，以20~29岁年龄段感染率最高（21.26%）(135/635)，其次为40~49岁年龄段（20.27%）(238/1 174)，HPV感染中以单一感染为主642例（66.60%）(642/964)。结论:HPV感染在苏州地区呈现单一、高危亚型感染为主的特征，该地区HPV感染亚型主要为52、81、16、58、53、51。

Epidemiological status of cervical HPV infection in women in Suzhou

Objective:To study the prevalence and genotype distribution of cervical human papillomavirus(HPV)infection in women of Suzhou and to provide evidence for cervical cancer prevention policy.Methods:Quantitative detection and typing of HPV in population sampled from July 2016 to March 2019 was carried out by polymerase chain reaction(PCR)combining with DNA hybridization genotyping technique.HPV infection status in Suzhou was analyzed.Results:There were 964 HPV positive cases in 4275 people,positive rate of 22.55%,and among them 812 cases were high-risk HPV(HR-HPV),positive rate was 84.23%.Twenty-three HPV subtypes detected were 52,81,16,58,53,51,68,56,42,33,18,66,59,11,43,31,39,6,45,35,82,83,73 with infection rate from high to low.Infection rates of HR-HPV in various age groups were different.Infection rate in samples in 20~29 years was highest(21.26%),followed by samples in 40~49 years(20.27%).The most common type of HR-HPV infection was single infection(66.60%).Conclusion:Prevalence of HPV infection in Suzhou is mainly single and high-risk subtype HPV infection.It is necessary to focus on prevention of HPV52,81,16,58,53,51 subtype persistent infection in this region.