Leptin and Insulin Action in Severely Obese Women |
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| Authors: | Papadia Francesco Marinari Giuseppe M Camerini Giovanni Civalleri Dario Scopinaro Nicola Adami Gian Franco |
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| Affiliation: | (1) Resident, Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy.;(2) Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy.;(3) Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy.;(4) Associate Professor of Surgery, Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy.;(5) Professor of Surgery, Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy.;(6) Associate Professor of Surgery, Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy. |
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| Abstract: | Background: The authors investigated the interrelationships between the components of the metabolic syndrome in severe obesity. Methods: In non-diabetic, severely obese women, the degree of obesity (BMI), the insulin sensitivity (from the Homeostatic Model of Assessment, HOMA), the serum leptin concentration and the presence of dyslipidemia and arterial hypertension were evaluated. Results: In insulin-resistant patients, an overall impaired metabolic status and a greater cardiovascular risk were observed, while serum leptin concentration was higher than in the insulin-sensitive ones. Leptin levels and HOMA data correlated independent of BMI findings, while the presence of dyslipidemia and hypertension was unrelated to the other metabolic syndrome factors. Conclusion: In severely obese women, although other factors independently intervene, serum leptin has a role in developing the metabolic syndrome. |
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| Keywords: | MORBID OBESITY INSULIN LEPTIN METABOLIC SYNDROME HYPERTENSION SERUM LIPIDS |
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