| 妊娠相关血浆蛋白-A与颈动脉粥样硬化斑块及缺血性脑血管病的关系 |
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| 引用本文： | 马芸,王小姗,庞伟,张玲莉,张雪玲. 妊娠相关血浆蛋白-A与颈动脉粥样硬化斑块及缺血性脑血管病的关系[J]. 临床神经病学杂志, 2010, 23(1) |
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| 作者姓名： | 马芸 王小姗 庞伟 张玲莉 张雪玲 |
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| 作者单位： | 1. 南京鼓楼医院集团宿迁市人民医院神经内科
2. 南京医科大学附属脑科医院老年神经科,210029 |
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| 摘 要： | 目的 探讨血清妊娠相关血浆蛋白(PAPP)-A与颈动脉粥样硬化斑块及缺血性脑血管病(ICVD)的关系.方法 116例首次发生颈内动脉系统ICVD的住院患者,包括急性脑梗死(ACI)72例和短暂性脑缺血发作(TIA)44例,另选38例体检者(对照组),均行头颅CT、颈动脉彩色多普勒超声仪及血清PAPP-A检查;根据颈动脉彩色多普勒超声仪检查结果,按斑块性质分为易损斑块组(39例)、稳定斑块组(60例)、内-中膜增厚组(20例)及无斑块组(35例),并对各项检查结果进行组问比较.结果 血清PAPP-A水平,ACI组[(5.64 ±1.92)mlU/L]及TAI组[(5.51±2.01)mlU/L]明显高于对照组[(4.12±1.98)mIU/L](均P＜0.05);各组中易损斑块组的血清PAPP-A水平明显高于无斑块组、内-中膜增厚组及稳定斑块组(均P＜0.05).PAPP-A对易损斑块、ACI、TIA的诊断评估显示曲线下面积(AUC)分别为0.87、0.61及0.57.结论 血清PAPP-A水平可作为诊断颈动脉粥样硬化易损斑块存在的生物学标记物,其血清水平的升高可视为 ICVD的危险因素之一.
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| 关 键 词： | 妊娠相关血浆蛋白-A 颈动脉粥样硬化 易损斑块 缺血性脑血管病 |
Relationship between pregnancy-associated plasma protein-A and carotid atherosclerotic plaque and ischemic cerebrovascular disease |
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| MA Yun,WANG Xiao-shan,PANG Wei,et al. Relationship between pregnancy-associated plasma protein-A and carotid atherosclerotic plaque and ischemic cerebrovascular disease[J]. Journal of Clinical Neurology, 2010, 23(1) |
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| Authors: | MA Yun WANG Xiao-shan PANG Wei et al |
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| Affiliation: | MA Yun,WANG Xiao-shan,PANG Wei,et al.Department of Geriatric Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective To investigate the relationship between pregnancy-associated plasma protein(PAPP-A)and carotid atherosclerotic plaque and ischemic cerebrovascular disease(ICVD).Methods 116 patients with first onset of ICVD in carotid artery system,including 72 cases with acute cerebral infarction(ACI group)and 44 cases with transient ischemic attck(TIA group),and 38 subjects(control group)were detected by craniocerebral CT and carotid color Doppler ultrasonography.And the serum PAPP-A of them were also be measure... |
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| Keywords: | pregnancy-associated plasma protein-A carotid arthrosclerosis vulnerable plaque ischemic cerebrovascular disease |
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