Prognostic significance of tumor deoxyribonucleic acid content in surgically resected small-cell carcinoma of lung. |
| |
Authors: | F A Carey U S Prasad W S Walker E W Cameron D Lamb C C Bird |
| |
Institution: | Department of Pathology, University of Edinburgh, United Kingdom. |
| |
Abstract: | The prognostic role of deoxyribonucleic acid flow cytometry was investigated in 53 cases of surgically resected small-cell lung cancer. Deoxyribonucleic acid aneuploidy was detected in 26 patients (49.1%), the remaining tumors being either diploid or tetraploid. Patients with aneuploid tumors had a significantly reduced 2-year survival (38.5%) when compared with patients with diploid or tetraploid tumors (70.3%; p less than 0.05). This finding was independent of tumor stage on multiple logistic regression analysis. Diploid or tetraploid deoxyribonucleic acid content was associated with a particularly good 2-year survival (85%) in N0 or N1 disease. Tumor deoxyribonucleic acid ploidy should be taken into account in planning of management and assessment of prognosis in small-cell lung cancer. |
| |
Keywords: | |
|