| 清炎颗粒对肾盂肾炎小鼠外周血IL-8与IL-10的影响 |
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| 引用本文： | 沈惠风,汤璐敏,王利民,李鹤,李群. 清炎颗粒对肾盂肾炎小鼠外周血IL-8与IL-10的影响[J]. 中国中西医结合肾病杂志, 2007, 8(12): 701-703 |
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| 作者姓名： | 沈惠风 汤璐敏 王利民 李鹤 李群 |
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| 作者单位： | 上海交通大学医学院附属仁济医院,上海,200127 |
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| 摘 要： | 目的：探讨清炎颗粒治疗肾盂肾炎的免疫学机制。方法：采用孙氏方法改进造模,治疗组分别按剂量3.12、6.24、12.48g·kg^-1·d^-1予清炎颗粒,模型组予生理盐水,对照组予至灵胶囊灌胃,喂养至3d、7d、15d、30d、60d取血清,用ELISA法检测其IL-8、IL-10的水平。结果：清炎颗粒能显著降低不同时段血清IL-8的水平、提高不同时段血清IL-10的水平。结论：免疫调控可能是清炎颗粒治疗肾盂肾炎的作用机制之一。
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| 关 键 词： | 肾盂肾炎 清炎颗粒 白细胞介素-8 白细胞介素-10 |
| 收稿时间： | 2007-02-10 |
| 修稿时间： | 2007-04-28 |
Effect of Qingyan Granula on IL-8 and IL-10 Releasing in Mice with Pyelonephritis |
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| SHEN Huifeng,TANG Lumin,WANG Limin,et alRenji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai. Effect of Qingyan Granula on IL-8 and IL-10 Releasing in Mice with Pyelonephritis[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2007, 8(12): 701-703 |
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| Authors: | SHEN Huifeng TANG Lumin WANG Limin et alRenji Hospital School of Medicine Shanghai Jiaotong University Shanghai |
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| Abstract: | Objective：To investigate the mechanism of Qingyan Granula in treating pyelonephritis, Methods：The mice model of pyelonephritis was established by incomplete unilateral ureter obstruction. Results： The serum IL- 8, IL- 10 in normal group, model group, control group（ Zhiling capsule）and Qingyan Granula groups（3.12,6.24,12.48 g·kg^-1·d^-1） were measured at 3rd day,7 th day,15 th day,30th day and 60th day by ELISA. Results The serum IL- 8 in Qingyan Granula groups was significantly lower than that in model group （P〈0.05） in different timepoints while the serum IL- 10 was significantly higher（P〈0.05）. Conclusion： Immunoregulation is one of the possible mechanisms of Qingyan Granula in treatment of pyelonephritis. |
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| Keywords: | Pyelonephritis Qingyan granula IL-8 IL-10 |
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