| 吲哚胺2,3二氧化酶与肿瘤免疫耐受 |
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| 引用本文： | 白燕南,王耀东,严茂林.吲哚胺2,3二氧化酶与肿瘤免疫耐受[J].医学综述,2009,15(13):1948-1950. |
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| 作者姓名： | 白燕南 王耀东 严茂林 |
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| 作者单位： | 福建医科大学省立临床医学院福建省立医院肝胆外科,福州,350001 |
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| 摘 要： | 肿瘤免疫耐受是一个获得性免疫应答的过程,许多机制参与调节。吲哚胺2,3-二氧化酶(IDO)是体内肝外色氨酸沿犬尿氨酸代谢的限速酶。其通过诱导"色氨酸删除"环境、色氨酸代谢产物的细胞毒性作用和调节Tregs等抑制T淋巴细胞增殖、活化,共同诱导肿瘤免疫耐受。抑制IDO可为今后肿瘤临床治疗提供新思路和方法。
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| 关 键 词： | 吲哚胺2 3-二氧化酶 肿瘤免疫耐受 吲哚胺2 3-二氧化酶抑制物 |
Indoleamine 2,3-dioxygenase and Tumor Immune Tolerance |
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| BAI Yan-nan,WANG Yao-dong,YAN Mao-lin.Indoleamine 2,3-dioxygenase and Tumor Immune Tolerance[J].Medical Recapitulate,2009,15(13):1948-1950. |
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| Authors: | BAI Yan-nan WANG Yao-dong YAN Mao-lin |
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| Institution: | BAI Yan-nan, WANG Yao-dong, YAN Mao-lin. (Department of Hepatobiliary Surgery, Provincial Hospital, Fujian Medical University, Fuzhou 350001, China) |
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| Abstract: | Tumor immune tolerance is a process of acquired immune response involving many mechanisms. Indoleamine 2,3-dioxygenase （ IDO ） is the rate-limiting enzyme in the kynurenine pathway of tryptohan catabolism. IDO induces tumor immune tolerance hemisphere, which can inhibit T cell proliferation/activation,via inducing ＂ tryptohan depletion＂ environment, eytotoxieity of tryptohan metabolite and modulating Tregs. The inhibitors of IDO may provide a prosperous therapeutic method for tumors. |
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| Keywords: | Indoleamine 2 3-dioxygenase - Tumor immune tolerance Indoleamine 2 3-dioxygenase inhibitor |
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