AP-1在皮肤肿瘤中的表达及其意义

背景与目的：转录激活蛋白AP-1与细胞的分化、增生、调亡以及肿瘤转化密切相关。本研究探讨AP-1亚单位在皮肤肿瘤及邻近皮肤组织中的表达及其与这些肿瘤发生、发展的关系。方法：采用免疫组织化学卵蛋白-生物素-辣根过氧化物酶法对皮肤基底细胞癌、鳞形细胞癌、原位癌、角化棘皮瘤及相邻皮肤组织中的c-jun，p—c-jun、JunB、JunD，c—fos、Fra-1和Fra-2进行分析。结果：c—jun和p—c-jun在皮肤基底细胞癌、鳞形细胞癌、原位癌和角化棘皮瘤肿瘤中表达明显增强，JunB在皮肤基底细胞癌中表达明显减弱。结论：c-jun是皮肤肿瘤形成及细胞增生的促进因素，JunB则是抑制因素。

Expression of AP-1 subunits in skin tumor and its significance

Purpose:AP-1(activator protein-1) is closely associated with cell differentiation,proliferation,apoptosis and tumorigenesis.We investigated the expression of AP-1 subunits in skin tumor and its adjacent skin tissue and their roles in the occurrence and development of skin tumor.Methods:ABC immunohistochemistry was applied to detect c-jun,p-c-jun,JunB,JunD,c-fos,Fra-1,and Fra-2 expression in skin basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma.Results:The expression of c-jun and p-c-jun were increased dramatically in basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma and JunB was decreased sharply in basal cell carcinoma.Conclusions:c-jun is a positive regulator of cell proliferation and tumorigenesis in skin.JunB has an antagonistic function for c-jun.