基质金属蛋白酶-2、-9在宫颈癌进展中的意义

目的探讨从宫颈癌前病变进展至宫颈癌，基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）的表达变化。方法采用免疫组化二步法检测20例慢性宫颈炎、45例宫颈上皮内瘤样变（CIN）、42例宫颈癌中MMP-2、MMP-9蛋白的表达。结果MMP-2、MMP-9在慢性宫颈炎中的表达极低，在各级CIN、宫颈浸润癌阳性表达高，其阳性表达强度随CIN级别增高而增强，至宫颈癌表达强度最高，并有统计学差异；在宫颈癌组织中，MMP-2的表达强度显著高于MMP-9，但宫颈癌的临床分期与MMP-9的表达强度有显著性关系，而与MMP-2的表达强度无显著性关系。结论MMP-2、MMP-9在宫颈癌前病变进展至宫颈癌这一过程中起着重要作用，而MMP-9与宫颈癌进展的关系更为密切，成为判断宫颈癌预后的指标之一。

The significance of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in the course of development of cervical carcinoma

Objective This study was undertaken to explore the significance of matrix metalloproteinase-2 （MMP- 2） and matrix metalloproteinase-9 （MMP-9） in the course of development of cervical carcinoma. Methods We evaluate samples of cervical tissue with immunohistochemistry for MMP-2 and MMP-9 in 5 distinct groups. The groups were divided into chronic cervicitis, CIN I, CIN II, CIN III and cervical invasive carcinoma. Result MMP-2 and MMP-9 expression gradually increased according to the degree of CIN and cervical carcinoma. The expression of MMP-2 was significantly higher than that of MMP-9, but the expression degree of MMP-9 was correlated with the clinical stage of carcinoma. Conclusion MMP-2 and MMP-9 play important roles in the process of CIN developing to carcinoma, but MMP-9 is more important according to the development of carcinoma, which might be a useful prognostic indicator for cervical cancer.