人乳头状瘤病毒(HPV)和P53蛋白在尖锐湿疣与阴茎癌中的表达

目的： 探讨ＨＰＶ 及Ｐ５３蛋白在尖锐湿疣和阴茎鳞癌中的表达情况。　方法： 在常规病理确定诊断后，用ＳＰ免疫组化法显示标本内的ＨＰＶ 抗原和Ｐ５３ 蛋白。　结果：尖锐湿疣２１ 例，ＨＰＶ标记均阳性，Ｐ５３ 蛋白标记５例见低度表达。阴茎鳞癌１９ 例，ＨＰＶ 标记阳性２例，Ｐ５３ 蛋白标记１２例见过度表达（阳性率６３％ ），其中６ 例强阳性。　结论：尖锐湿疣与ＨＰＶ 感染有关，少数见Ｐ５３ 蛋白低度表达；而阴茎鳞癌中常见Ｐ５３蛋白过度表达，少数可能与ＨＰＶ感染有关。

Detection of HPV and P53 protein in condylomata acuminatum and squamous cell carcinoma of penis

Objectives:To detect the expression of HPV antigen and P53 protein in condylomata acuminatum (CA) and squamous cell carcinoma (SCC) of penis. Methods: After routine pathologic diagnosis, the specimens were immunostained with rabbit anti human papilloma virus antibody and mouse anti human P53 protein antibody(S P method). Results: HPV antigen was detected in all 21 CA and 2 SCC of penis. The overexpression of P53 protein was observed in 12 SCC of penis (12 of 19, 64%) in which 6 were strong positive. Five of 21 CA (24%) were low P53 protein expresion. Conclusions:CA is related to HPV infection and some with low expression of P53 protein. In contrast, the overexpression of P53 protein is often observed in SCC of penis and few cases related to HPV infection.