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Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced,unresectable hepatocellular carcinoma
Authors:Lynn G. Feun MD  Ying-Ying Li PhD  Chunjing Wu MS  Medhi Wangpaichitr PhD  Patricia D. Jones MD  Stephen P. Richman MD  Beatrice Madrazo MD  Deukwoo Kwon PhD  Monica Garcia-Buitrago MD  Paul Martin MD  Peter J. Hosein MD  Niramol Savaraj MD
Affiliation:1. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida;2. Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida;3. Division of Hematology and Oncology, Miami Veterans Affairs Healthcare System, Miami, Florida;4. Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida;5. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida

Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida;6. Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida;7. Biostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida;8. Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida;9. Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida

Division of Hematology and Oncology, Miami Veterans Affairs Healthcare System, Miami, Florida

Abstract:
Keywords:circulating biomarkers  clinical trial  hepatocellular carcinoma  pembrolizumab  programmed death–ligand 1 (PD-L1) expression  sorafenib
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