Silver carbene complexes: An emerging class of anticancer agents |
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| Authors: | Shravankumar Kankala Niranjan Thota Fredrik Björkling Myles K. Taylor Ravinder Vadde Ramesh Balusu |
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| Affiliation: | 1. Department of Chemistry, Kakatiya University, Warangal, Telangana State, India;2. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;3. University of Kansas Medical Center, Kansas City, Kansas |
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| Abstract: | Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies. |
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| Keywords: | antineoplastic drug design mechanistic study mitochondria silver carbene complexes |
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