万古霉素致失代偿期肝硬化患者重度血小板减少1例

万古霉素是一种糖肽类抗生素,临床主要用于治疗包括耐甲氧西林金黄色葡萄球菌在内的侵袭性革兰阳性菌感染。该药常见不良反应为皮疹、肾毒性及耳毒性,较少引起血小板减少。本文报道1例由万古霉素导致重度血小板减少的失代偿期肝硬化患者,为此类不良反应的临床监测及治疗提供参考。

Severe thrombocytopenia caused by vancomycin in one case with decompensated cirrhosis

Vancomycin is a glycopeptide antibiotic used for clinical treatment of invasive gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus. Adverse effects of vancomycin include rash, nephrotoxicity and ototoxicity. But thrombocytopenia is rare. This study reports one patient with decompensated cirrhosis of severe thrombocytopenia caused by vancomycin, and provides a reference for the monitoring and treatment of clinical adverse reactions for vancomycin.