双黄连注射液导致类过敏的物质基础及作用机理

双黄连注射液由金银花、黄芩、连翘制备而成，可清热解毒、宣散风热，作用迅速，有良好的生物利用度，临床上治疗上呼吸道感染、肺炎、扁桃体炎等病症，均取得了良好的效果。近年中药注射剂所致不良反应显著增多，双黄连注射液所导致的不良反应总是排列在首位，其不良反应涉及人体多个系统和器官，如皮肤、消化系统、心血管等系统的损伤，严重者甚至会发生过敏性休克。目前双黄连注射液致敏原因尚存争议，本文从中医理论、物质基础、类过敏反应的机制等方面综述，对其导致类过敏的原因进行讨论，以求为增加双黄连注射液的安全性提供建议。

Material Basis and Mechanism of Anaphylactoid Induced by Shuanghuanglian Injection

Shuanghuanglian injection is a Chinese formula prepared from three Traditional Chinese Medicines (TCMs) including Lonicera Japonica (Jinyinhua), Radix Scutellariae (Huangqin) and Fructus Forsythiae (Lianqiao), which can clear heat and detoxify, disperse wind and heat, act quickly, have good bioavailability, and have good results in the treatment of upper respiratory tract infection, pneumonia, tonsillitis and other diseases. In recent years, the adverse reactions caused by traditional Chinese medicine injection have increased significantly, and the adverse reactions caused by Shuanghuanglian injection are always in the first place. the adverse reactions involve the injury of many systems and organs of the human body, such as skin, digestive system, cardiovascular system and so on. In severe cases, anaphylactic shock may even occur. At present, the cause of sensitization of Shuanghuanglian injection is still controversial. This article will review the theory of traditional Chinese medicine, the material basis, the mechanism of anaphylactoid and other aspects, and discuss the causes of anaphylactoid, in order to provide suggestions for increasing the safety of Shuanghuanglian injection.