阻塞性睡眠呼吸暂停低通气综合征合并心血管疾病患者同型半胱氨酸和血脂水平的检测分析

目的:检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并心血管疾病(CVD)患者的同型半胱氨酸(Hcy)和血脂水平,探讨其在OSAHS合并CVD中的作用。方法:收集本院OSAHS64例,分为单纯OSAHS组、OSAHS+CVD组,并选择单纯CVD和健康人群作为对照,分别行整夜多导睡眠监测(PSG)。测定呼吸暂停低通气指数(AHI)和血氧饱和度(SaO2)。同时采集空腹静脉血,检测血清Hcy以及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果:OSAHS+CVD组的Hcy高于正常对照组、单纯OSAHS组和单纯CVD组(P<0.01);单纯OSAHS组、OSAHS+CVD组和单纯CVD组的TC、TG、LDL-C值均比正常对照组高(P<0.05~0.01),HDL-C值比正常对照组低(P<0.01),但三疾病组间无统计学差异。结论:OSAHS患者Hcy水平升高可能是OSAHS患者易患高血压、冠心病等心血管疾病的机制之一。

Serum Homocysteine and blood fat Levels in Obstructive Sleep Apnea-Hyperpnoea Syndrome Patients with Cardiovascular Disease

Objective: To examine the levels of homocysteine(Hcy) and blood fat in patients with obstructive sleep apnea-hyperpnoea syndrome (OSAHS), and to investigate the role of the homocysteine played in the process of OSAHS with cardiovascular disease.Method: Collect 64 patients with OSAHS from the renmin hospital of wuhan university, fasting serum Hcy levels and blood fat were measured in OSAHS without CVD patients, OSAHS with CVD patients and CVD patients. Meanwhile, total cholesterol (TC),triglyceride(TG),high-density lipoproteins (HDL-C),low-density lipoproteins (LDL-C) were also measured.Results: The levels of Hcy were higher in OSAHS with CVD patients than that in OSAHS without CVD patients and CVD patients (P<0.01). The serum TC,TG,LDL-C levels in OSAHS patients with and without CVD and CVD patients were higer than healthy patients. The serum HDL-C level in OSAHS patients with and without CVD and CVD patients was lower than healthy patients. There were no difference in all three groups above.Conclusion: Hcy levels were higher in OSAHS with cardiovascular diseases. Therefore they could be the important mechanisms for the OSAHS patients who would easily to contract cardiovascular diseases.