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枸杞果柄对四氧嘧啶糖尿病小鼠血糖的影响
引用本文:杨涓,陈炜,魏智清. 枸杞果柄对四氧嘧啶糖尿病小鼠血糖的影响[J]. 时珍国医国药, 2009, 20(7)
作者姓名:杨涓  陈炜  魏智清
作者单位:1. 宁夏大学生命科学学院,宁夏,银川,750021
2. 宁夏检验检疫局,宁夏,银川,750001
摘    要:目的 探讨枸杞果柄水煎剂对四氧嘧啶糖尿病小鼠血糖的影响.方法 制备四氧嘧啶糖尿病小鼠模型,将其分为降糖灵治疗组、低剂量枸杞果柄治疗组、高剂量枸杞果柄治疗组、模型对照组,另设正常对照组(非糖尿病小鼠).前3组小鼠分别以25 mg·kg-1·d-1降糖灵水溶液、5.0 g·kg-1·d-1枸杞果柄水煎剂、7.5 g·kg-1·d-1枸杞果柄水煎剂灌胃,后2组小鼠均灌服等量的生理盐水.14 d后测定小鼠空腹血糖.结果 给药14 d后降糖灵治疗组、低剂量枸杞果柄治疗组小鼠血糖较治疗前有极显著下降(P<0.01),高剂量枸杞果柄治疗组小鼠血糖较治疗前有显著下降(P<0.05);降糖灵治疗组、不同剂量枸杞果柄治疗组血糖降低平均值与模型对照组、正常对照组血糖变化平均值之间均存在极显著差异(P<0.01).结论 一定剂量的枸杞果柄水煎剂对四氧嘧啶糖尿病小鼠血糖有降低作用.

关 键 词:枸杞果柄  糖尿病小鼠  降血糖

Effect of Fruit Pedicels of Lycium barbarum L.on Blood Glucose in Alloxan Induced Diabetic Mice
YANG Juan,CHEN Wei,WEI Zhi-qing. Effect of Fruit Pedicels of Lycium barbarum L.on Blood Glucose in Alloxan Induced Diabetic Mice[J]. Lishizhen Medicine and Materia Medica Research, 2009, 20(7)
Authors:YANG Juan  CHEN Wei  WEI Zhi-qing
Abstract:Objective To investigate the effect of fruit pedicels of Lycium barbarum L.decoction on blood glucose in alloxan-induced diabetic mice.Methods Alloxan-induced diabetes mellitus mice were fed with either 25 mg·kg-1·d-1 Jiangtangling,a clinic medicine for diabetes,or different concentrations of decocta of fruit pedicels of Lycium barbarum L.(low dosage:5.0 g·kg-1·d-1 or high dosage:7.5 g·kg-1·d-1.For controls,both Alloxan-induced diabetic mice or normal mice were fed with equal amount of saline.The blood glucose level of all five group mice was measured 14 d after treatment.Mice were fasted before blood samples were obtained.Results Both Jiangtangling and low dose of fruit pedicels of Lycium barbarum L.could significantly decrease mouse blood sugar compared to pretreatment (P<0.01),so did high dose decota of fruit pedicels of Lycium barbarum L.(P<0.05).Both Jiangtangling and different doses of fruit pedicels of Lycium barbarum L.could significantly reduce blood glucose levels as compared to model group or normal group (P<0.01).Conclusion The decoction of fruit pedicels of Lycium barbarum L.can reduce blood glucose level in alloxan-induced diabetic mice.
Keywords:Fruit pedicels of Lycium barbarum L.  Diabetic Mice  Hypoglycemic
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