| 重症肌无力患者血清TGF-β1和sICAM-1的检测及其临床意义 |
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| 引用本文： | 何志义,欧阳嶷,侯率,陈晏,李润辉,吕昌龙. 重症肌无力患者血清TGF-β1和sICAM-1的检测及其临床意义[J]. 神经疾病与精神卫生, 2001, 1(2): 15-17 |
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| 作者姓名： | 何志义 欧阳嶷 侯率 陈晏 李润辉 吕昌龙 |
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| 作者单位： | 1. 110001,中国医科大学第一临床学院神经内科
2. 中国医科大学基础医学院免疫学教研室 |
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| 摘 要： | 目的探讨转化生长因子-β1(TGF-β1)及可溶性细胞间粘附分子(sICAM-1)在重症肌无力(MG)发病中的作用及其临床意义.方法采用酶联免疫吸附ELISA方法,测定了32例MG患者及30名正常对照组(NC)血清TGF-β1和sICAM-1的水平.结果与NC组相比,MG患者血清TGF-β1明显降低(P＜0.01),而sICAM-1水平则明显升高(P＜0.01).与轻型组比较,重型组TGF-β1水平明显降低(P＜0.01),而sICAM-1水平则明显升高(P＜0.01).动态观察显示,治疗后随着病情的好转,TGF-β1水平逐渐升高,而sIMCA-1水平则逐渐下降.结论TGF-β1和sICMA-1可能参与了MG的发病机制,且与病情的轻重有密切关系.
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| 关 键 词： | sICAM-1 TGF-β1 患者 血清 重症肌无力 升高 临床意义 水平 结论 参与 |
| 文章编号： | 1009-6574(2001)02-0015-03 |
| 修稿时间： | 2000-12-13 |
The Detection and Clinical Significance of the Serum TGF-B1 and sICAM-1 in Patients with Myasthe-nia Gravis |
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| He Zhiyi,Ouyang Yi,Hou Shuai,et al.. The Detection and Clinical Significance of the Serum TGF-B1 and sICAM-1 in Patients with Myasthe-nia Gravis[J]. Nervous Diseases and Mental Health, 2001, 1(2): 15-17 |
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| Authors: | He Zhiyi Ouyang Yi Hou Shuai et al. |
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| Abstract: | Objective To study the pathogenic mechanism and clinical significance of transforming growth factor-B1 (TGF-B1 ) and soluble intercellular adhesion molecule-1 (sICAM-1) in myasthenia gravis (MG). Methods The TGF-B1 and sICAM-1 level in serum were measured in 32 patients with MG and 30 normal controis(NC) by ELISA method. Results Comparing with NC group, The TGF-B1 level decreased, and the sICAM-1 level increased significantly in the serum of MG( P <0.01). The level of TGF - B1 and sICAM-1 in the patients with MG correlated directly with the severity of the diseases. The level of sICAM-1 decreased, and the TGF-B1 level increased after treatment of MG. Conclusions The results suggested the TGF-B1 and sICAM-1 system was involved in the pathogenic mechanism of MG, and might have an evident correlation with the severity of this disease. |
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| Keywords: | Myasthenia gravis TGF-B1 sICAM-1 |
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