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Phellinus baumii ethyl acetate extract alleviated collagen type II induced arthritis in DBA/1 mice |
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| Authors: | Taddesse Yayeh Whi Min Lee Dukhwan Ko Seung-Choon Park Jae Youl Cho Hwa-Jin Park In-Kyoung Lee Seung-Hyung Kim Seung-Bok Hong Suk Kim Bong-Sik Yun Man Hee Rhee |
| Affiliation: | 1. Laboratory of Veterinary Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea 8. Department of Orthopaedic Surgery, Medical School, Konkuk University, Chungju, Republic of Korea 2. School of Life science and Biotechnology, Sungkyunkwan University, Suwon, 440-746, Republic of Korea 3. College of Biomedical Science and Engineering, Regional Research Center, Inje University, Gimhae, 621-749, Republic of Korea 4. College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, 570-752, Republic of Korea 5. Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, 300-716, Republic of Korea 6. Department of Clinical Laboratory Science, Chungbuk Health and Science University, Chungbuk, 363-794, Republic of Korea 7. College of Veterinary Medicine, Gyeongsang National University, Jinju, 660-701, Republic of Korea |
| Abstract: | Mushrooms have a long history of dietary benefits in Asia due to their health-promoting effects. Phellinus baumii, a wild mushroom, has been reported to have anti-platelet, anti-inflammatory, anti-obesity and free radical scavenging activities. However, its anti-rheumatoid arthritis (RA) property remains poorly understood. Hence, we investigated the protective effect of Phellinus baumii ethyl acetate extract (PBEAE) against bovine collagen type II induced arthritis (CIA) in DBA/1 mice. PBEAE (50 and 150 mg/kg) reduced the CIA score and leukocyte count in draining lymph nodes (DLNs) and inflamed joints. PBEAE also attenuated the expressions of CD3+ (T cells), CD19+ (B cells), CD4+ (T-helper), CD8+ (T-cytotoxic), MHC class II/CD11c+ (antigen-presenting cells), double positives (B220+/CD23+ and CD3+/CD69+: early lymphocyte activation markers) and CD4+/CD25+ (activated T-helper) leukocyte subpopulations in DLNs. Likewise, CD3+ and Gr-1+CD11b+ (neutrophil) counts in inflamed joints were also decreased. Furthermore, PBEAE reduced the serum levels of anti-collagen type immunoglobulin G, tumor necrosis factor-α and interleukin (IL)-1β and IL-6. Taken together, PBEAE impaired cellular recruitment to the inflamed joint and alleviated CIA, and thus could be considered as a potential agent against rheumatoid arthritis |
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