| 尿激酶型纤溶酶原激活因子及其受体在人脑胶质瘤中的表达和意义 |
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| 引用本文： | 陈剑,姚东晓,赵洪洋.尿激酶型纤溶酶原激活因子及其受体在人脑胶质瘤中的表达和意义[J].中国临床神经外科杂志,2005,10(2):101-104. |
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| 作者姓名： | 陈剑 姚东晓 赵洪洋 |
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| 作者单位： | 1. 济宁市第一人民医院神经外科,山东,济宁,272111
2. 华中科技大学同济医学院附属协和医院神经外科,湖北,武汉,430022 |
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| 摘 要： | 目的探讨尿激酶型纤溶酶原激活剂(urokinase-type plasminogen activator，uPA)及其受体(uPAR)的表达与人脑胶质瘤恶性程度的关系。方法采用免疫组化法，对58例人脑胶质瘤手术切除标本，10例内减压术中切除的正常脑组织标本的uPA、uPAR蛋白表达水平进行检测。结果随着胶质瘤恶性度的升高，其uPA、uPAR蛋白表达率和表达水平逐渐增高，而在正常组织中均无uPA和uPAR表达。结论uPA／uPAR蛋白高表达反映了胶质瘤的恶性生物学行为。
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| 关 键 词： | 尿激酶型纤溶酶原激活剂 尿激酶型纤溶酶原激活剂受体 胶质瘤 |
| 文章编号： | 1009-153X(2005)02-0101-04 |
| 修稿时间： | 2004年5月18日 |
Expressions and Significances of Urokinase-type Plasminogen Activator and its Receptor in Human Gliomas |
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| CHEN Jian,YAO Dong-xiao,ZHAO Hong-yang.Expressions and Significances of Urokinase-type Plasminogen Activator and its Receptor in Human Gliomas[J].Chinese Journal of Clinical Neurosurgery,2005,10(2):101-104. |
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| Authors: | CHEN Jian YAO Dong-xiao ZHAO Hong-yang |
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| Institution: | CHEN Jian,YAO Dong-xiao,ZHAO Hong-yang. Department of Neurosurgery,Union Hospital,Tongji Medical School,Huazhong University of Sciences and Technology,Wuhan Hubei 430022,China |
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| Abstract: | Objectives To study the expressions of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in the gliomas, and to analysis the relationship between uPA and uPAR expressions and the grade of human gliomas. Methods The levels of uPA and uPAR protein expressions were determined by immunohistochemical technique in 58 cases of the gliomas and 10 samples of the normal brain tissue. Results The expressions of uPA and uPAR were not detected in normal brain tissures, and positively correlated with the pathological grade of the gliomas (P<0.01). Conclusions The high levels of uPA and uPAR expressions may reflect a malignant biological behavior of the glioma cells. |
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| Keywords: | uPA uPAR Glioma Expression Immunohistochemical technique |
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