| 双歧杆菌对溃疡性结肠炎大鼠肠黏膜屏障功能及细胞因子的影响 |
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| 引用本文： | 王旭霞,赵曙光,刘震雄,朱少君,唐华,卢王,雷巧玲,王景杰. 双歧杆菌对溃疡性结肠炎大鼠肠黏膜屏障功能及细胞因子的影响[J]. 山西医科大学学报, 2011, 42(8): 621-623,694. DOI: 10.3969/J.ISSN.1007-6611.2011.08.003 |
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| 作者姓名： | 王旭霞 赵曙光 刘震雄 朱少君 唐华 卢王 雷巧玲 王景杰 |
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| 作者单位： | 第四军医大学唐都医院消化内科,西安,710038 |
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| 摘 要： | 目的观察双歧杆菌活菌制剂对溃疡性结肠炎(UC)大鼠肠黏膜屏障功能及细胞因子的影响,为溃疡性结肠炎的治疗提供理论依据。方法采用饮用DSS(dextran sulfacte sodium)水溶液,建立UC动物模型。饮用DSS的大鼠(n=30)随机分为3组,给予不同的药物治疗,不同药物皆以溶液形式灌胃给药:双歧杆菌治疗组(A组);美沙拉嗪治疗组(B组);模型组(C组),UC模型大鼠每天饮用与药物等体积的生理盐水。同时设立正常对照组(D组):饮用与药物等体积的生理盐水。检测治疗前、后各组大鼠MPO活性、IL-6、IL-8、TNF-α水平,并取肠道标本观察肠黏膜变化情况。结果与模型组比较,治疗后A组、B组髓过氧化物酶(MPO)活性及结肠损伤组织学评分(CMDI)均下降(P<0.05),IL-6、IL-8、TNF-α水平也明显下降(P<0.05),A组与B组间各指标差异无统计学意义(P>0.05)。结论双歧杆菌可通过降低肠道通透性,调节抑制细胞因子,对大鼠DSS结肠炎肠道黏膜发挥保护作用。
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| 关 键 词： | 双歧杆菌 溃疡性结肠炎 髓过氧化物酶 TNF-α IL-6 IL-8 |
Effects of bifidobacterium on intestinal mucosal barrier function and cytokines in rats with ulcerative colitis |
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| WANG Xu-xia,ZHAO Shu-guang,LIU Zhen-xiong,ZHU Shao-jun,TANG Hua,LU Wang,LEI Qiao-ling,WANG Jing-jie. Effects of bifidobacterium on intestinal mucosal barrier function and cytokines in rats with ulcerative colitis[J]. Journal of Shanxi Medical University, 2011, 42(8): 621-623,694. DOI: 10.3969/J.ISSN.1007-6611.2011.08.003 |
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| Authors: | WANG Xu-xia ZHAO Shu-guang LIU Zhen-xiong ZHU Shao-jun TANG Hua LU Wang LEI Qiao-ling WANG Jing-jie |
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| Affiliation: | WANG Xu-xia,ZHAO Shu-guang,LIU Zhen-xiong,ZHU Shao-jun,TANG Hua,LU Wang,LEI Qiao-ling,WANG Jing-jie(Dept of Gastroenterology,Tangdu Hosptial,Fourth Military Medical University,Xi'an 710038,China) |
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| Abstract: | Objective To explore the effects of bifidobacterium on intestinal mucosal barrier function and cytokines in rats with ulcerative colitis(UC),and provide a basis for treating UC.Methods Rats were treated with dextran sulfacte sodium solution to establish rat model of ulcerative colitis,and then model rats were randomized into three groups.Rats were administrated with bifidobacterium in group A,mesalazine in group B and saline solution in group C by oral gavage.Rats in group D were not given any drugs except ... |
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