| 贝那普利对肝纤维化大鼠胰岛样生长因子结合蛋白-2表达的影响 |
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| 引用本文： | 赵彩霞,申凤俊,唐瑾.贝那普利对肝纤维化大鼠胰岛样生长因子结合蛋白-2表达的影响[J].山西医科大学学报,2011,42(11):861-863,937. |
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| 作者姓名： | 赵彩霞 申凤俊 唐瑾 |
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| 作者单位： | 山西医科大学第一临床医学院消化科,太原,030001 |
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| 摘 要： | 目的研究血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)贝那普利对大鼠肝纤维化的疗效以及对肝纤维化大鼠胰岛素样生长因子结合蛋白-2(insulin-like growth factor binding protein-2,IGFBP-2)表达的影响。方法22只健康雄性Wistar大鼠随机分为3组:正常对照组(n=6),模型组(n=8),贝那普利预防治疗组(n=8)。除正常对照组外,模型组和贝那普利预防治疗组均给予大鼠首次皮下注射40%CCl4油剂5 ml/kg,以后每次皮下注射40%CCl4 2 ml/kg,每周两次。给予正常对照组相同剂量的油剂皮下注射。同时贝那普利预防治疗组从实验第1天开始给予贝那普利10 mg/(kg.d)灌胃,直至实验结束。于8周末,分别杀死大鼠,留取血及肝组织标本备用。肝组织进行常规HE及Masson三色染色,酶联免疫法测定血清IGFBP-2,免疫组织化学染色肝组织IGFBP-2。结果贝那普利有明显抗大鼠肝纤维化的疗效,模型组IG-FBP-2在血清和肝组织的表达增加(P<0.05),贝那普利预防治疗组比模型组血清和肝组织IGFBP-2的表达减少(P<0.05)。结论贝那普利抗肝纤维化的机制可能与其降低血清及肝组织IGFBP-2的表达有关。
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| 关 键 词： | 肝纤维化 胰岛样生长因子结合蛋白-2 大鼠 |
Effect of benazepril on insulin-like growth factor binding protein-2 expression in hepatic fibrosis rats |
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| ZHAO Cai-xia,SHEN Feng-jun,TANG Jin.Effect of benazepril on insulin-like growth factor binding protein-2 expression in hepatic fibrosis rats[J].Journal of Shanxi Medical University,2011,42(11):861-863,937. |
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| Authors: | ZHAO Cai-xia SHEN Feng-jun TANG Jin |
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| Institution: | ZHAO Cai-xia,SHEN Feng-jun,TANG Jin(Dept of Gastroenterology,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Objective To explore the protective effects of angiotensin converting enzyme inhibitor(ACEI) benazepril on insulin-like growth factor binding protein-2(IGFBP-2) expression in rats of hepatic fibrosis induced by carbon tetrachloride(CCl4).Methods Hepatic fibrosis was induced by intraperitoneal injection of carbon tetrachloride(CCl4) in rats.Twenty-two Wistar male rats were randomly divided into normal control group(n=6),model group(n=8),benazepril treatment group(n=8).The rats in model group and benazepril t... |
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| Keywords: | hepatic fibrosis insulin-like growth factor binding protein-2 rats |
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