| 丙泊酚及缺血预处理对大鼠肝缺血－再灌注损伤时细胞凋亡的影响 |
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| 引用本文： | 王敬宇,曹定睿,毛惠斌,王建刚,杨春艳.丙泊酚及缺血预处理对大鼠肝缺血－再灌注损伤时细胞凋亡的影响[J].山西职工医学院学报,2008,18(3):6-8. |
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| 作者姓名： | 王敬宇 曹定睿 毛惠斌 王建刚 杨春艳 |
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| 作者单位： | 山西医科大学第一医院,山西,太原,030001 |
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| 摘 要： | 目的：探讨丙泊酚及缺血预处理对大鼠肝脏缺血－再灌注损伤时细胞凋亡的影响。方法：成年健康SD大鼠72只，随机分为4组：假手术组（Sham组）、缺血－再灌注组（IR组）、缺血预处理组（IP组）、丙泊酚组（P组）。制作70％肝脏缺血－再灌注模型，实验结束后即刻取肝左叶。用免疫组化法检测Bcl-2与Bax蛋白表达量，TUNEL法检测肝细胞凋亡指数（AI）。结果：与Sham组比较，各组肝组织Bcl-2、Bax蛋白表达水平、凋亡指数均增加（P〈0．05）；与IR组比较，IP、P组Bcl-2蛋白表达增加、Bax蛋白表达和AI减少（P〈0．05）；与IP组比较，P组Bcl-2蛋白表达增加、Bax蛋白表达和AI减少（P〈0、05）。结论：丙泊酚及缺血预处理通过调节Bcl-2、Bax蛋白表达，使肝细胞凋亡减轻，对大鼠缺血再灌注肝脏可能有一定的保护作用。
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| 关 键 词： | 丙泊酚 缺血预处理 肝 再灌注损伤 凋亡 |
Effects of Propofol and Ischemic Preconditioning on Cell Apoptosis Induced by Hepatic Ischemia-Reperfusion Injury in Rats |
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| WANG Jingyu,CAO Dingrui,MAO Huibin,WANG Jiangang,YANG Chunyan.Effects of Propofol and Ischemic Preconditioning on Cell Apoptosis Induced by Hepatic Ischemia-Reperfusion Injury in Rats[J].Journal of Shanxi Medical College For Continuing Education,2008,18(3):6-8. |
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| Authors: | WANG Jingyu CAO Dingrui MAO Huibin WANG Jiangang YANG Chunyan |
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| Institution: | ( The First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China) |
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| Abstract: | Objective:To investigate the effects of propofol and ischemic preconditioning on cell apoptosis induced by hepatic ischemia-reperfusion injury in rats.Methods: Seventy-two adult healthy SD rats were randomly divided into 4 groups(n=18).They were a sham-operated group(Sham group),an ischemia-reperfusion group(IR group),an ischemic preconditioning group(IP group)and a propofol group(P group).A 70% hepatic ischemia-reperfusion model was made and the left hepatic lobes were sampled after the experiment.The expr... |
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| Keywords: | propofol ischemic preconditioning liver reperfusion injury apoptosis |
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