fPSA/tPSA比值在前列腺癌和前列腺增生鉴别中的意义

目的 探讨fPSA/tPSA比值在前列腺癌和前列腺增生鉴别中的意义。方法 回顾分析了2000年9月-2001年8月期间在我院住院治疗的72例前列腺癌和前列腺增生患者的tPSA和fPSA/tPSA比值。结果 72例患者中,前列腺增生48例,前列腺癌24例。tPSA为4.0～10.0ng/ml之间时,前列腺癌患者3例,其fPSA/tPSA平均值为0.12,而前列腺增生患者有16例,其fPSA/tPSA平均值为0.21,两者差异明显。tPSA为4.0～10.0ng/ml,fPSA/tPSA比值为0.20,诊断前列腺癌的特异性为61％,而敏感性为100％。结论 当tP-SA为4.0～10.0ng/ml时,fPSA/tPSA比值作为一种参考标准可以用于临床筛选潜在的前列腺癌患者。

Significance of fPSA/tPSA in the differential diagnosis of benign prostatic hyperplasia and prostatic carcinoma

Objective To investigate the value of fPSA/tPSA in the differential diagnosis of benign prostatic hy-perplasia(BPH)and prostate carcinoma(Pca). Methods fPSA and fPSA/tPSA ratio were retros pectively analyzed in 72 patients with BPH and Pea in our hospital from Sept. 2000 to Aug. 2001. Kruskal-Wallis test?t-test and Mann -Whitney nonparametric analysis were performed to account for differences of fPSA/PSA ratio between patients with BPH or Pea . Results There were 48 patients with BPH and 24 patients with Pea. When rPSA was from 4. 0 to 10. 0 ng/ml , there were 3 patients with Pea whose mean fPSA/tPSA ratio was 0.12, However , the mean fPSA/tPSA ratio of BPH was 0.21 . There was statistical difference between them . When tPSA was from 4.0 to 10.0ng/ml, the obstained specificity values at a cutoff level of 0.20 for the proportion of fPSA and a sensitivity level of 100 % was 61 % . Conclusion These data indicate that more potential Pea may be screened by measuring fPSA/tPSA ratio if tPSA is from 4.0tol0.0ng/ml .