Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases |
| |
Authors: | Christine Rohowsky-Kochan Donna Eiman Raymond Troiano Shalini Bansil James Oleske Tom Denny Stuart D Cook |
| |
Institution: | University of Medicine & Dentistry of New Jersey, New Jersey Medical School, Newark 07103. |
| |
Abstract: | Decreased numbers of CD4+CD45R+ suppressor-inducer T cells have been reported in patients with a variety of autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis but not in patients with other neurological diseases. We now report our findings using murine monoclonal antibodies and two-color flow cytometric analysis on CD4+CD45R+ T cells in 22 patients with chronic progressive multiple sclerosis, 23 patients with other neurological diseases and 42 normal, healthy controls. Suppressor-inducer T cells were significantly reduced (p less than 0.001) in both patients with multiple sclerosis and other neurological diseases as compared to controls. Both patient populations had elevated helper T cell subset ratios. Thus, our data suggests that decreases in suppressor-inducer T cells may represent a common immunological defect among autoimmune and presumably non-autoimmune neurological disorders. |
| |
Keywords: | Suppressor-inducer cell Multiple sclerosis Autoimmune and non-autoimmune neurological disorder Immunofluorescence cytometry |
本文献已被 ScienceDirect 等数据库收录! |