| cAMP类似物对人乳腺癌细胞cyclinD1表达的影响 |
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| 引用本文： | 王锦华,陈奎生,张云汉,罗伟. cAMP类似物对人乳腺癌细胞cyclinD1表达的影响[J]. 安徽医药, 2003, 7(6): 438-439 |
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| 作者姓名： | 王锦华 陈奎生 张云汉 罗伟 |
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| 作者单位： | 1. 河南省郑州市第三人民医院病理科,郑州,450000
2. 郑州大学一附院病理科,河南省肿瘤病理重点实验室,郑州,450052 |
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| 摘 要： | 目的：探讨cAMP类似物对人乳腺癌细胞增殖相关cyclinD1基因表达的影响。方法 体外分组原代培养人乳腺癌细胞，采用原位杂交方法研究cAMP类似物对人乳腺癌细胞中cyclin D1基因表达的变化。结果 8-Br-cAMP、8-Cl-cAMP均下调乳腺癌细胞中cyclin D1基因表达，且后下降作用更明显。结论 cAMP类似物可通过影响与乳腺癌细胞增殖相关cyclin D1表达从而抑制乳腺癌细胞生长。
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| 关 键 词： | 乳腺癌 cAMP类似物 cyclinD1基因 细胞增殖 基因表达 |
Effect of cAMP analogs on cyclinD1 expression of human breast cancer cells |
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| WANG Jin Hua,CHEN Kui Sheng ,ZHANG Yun Han ,LUO Wei. Effect of cAMP analogs on cyclinD1 expression of human breast cancer cells[J]. Anhui Medical and Pharmaceutical Journal, 2003, 7(6): 438-439 |
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| Authors: | WANG Jin Hua CHEN Kui Sheng ZHANG Yun Han LUO Wei |
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| Affiliation: | WANG Jin Hua,CHEN Kui Sheng 1,ZHANG Yun Han 1,LUO Wei |
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| Abstract: | AIM To study the effect of cAMP analogs on cyclinD1, expression of human breast cancer cells. METHODS After the human breast cancer cells were cultured, the alteration of cyclinD1 gene expression was studied by in situ hybridization. RESULTS 8 Br cAMP, 8 Cl cAMP could reduce the expression of cyclinD1, the effect of 8 Cl cAMP was stronger than that of 8 Br cAMP. CONCLUSION cAMP analogs could inhibit the grouth of human breast cancer celols by affecting the cyclinD1 gene expression. |
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| Keywords: | cAMP analogs breast carcinoma cyclinD1 in situ hybridization |
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