甲氨蝶呤联合平阳霉素双侧子宫动脉灌注治疗剖宫产瘢痕妊娠疗效及安全性研究

目的 探讨双侧子宫动脉灌注甲氨蝶呤及平阳霉素治疗剖宫产瘢痕妊娠(CSP)的临床疗效,以及对阴道出血情况的影响.方法 选取秦皇岛军工医院2018年5月至2020年1月收治的CSP孕妇102例,随机分为观察组和对照组,各51例.两组患者均予注射用甲氨蝶呤,观察组患者加用注射用盐酸平阳霉素,均双侧子宫动脉灌注给药,每日1次,...

Efficacy and Safety of Bilateral Uterine Artery Infusion of Methotrexate and Pingyangmycin in the Treatment of Patients with Cesarean Scar Pregnancy

Objective To investigate the clinical efficacy of bilateral uterine artery infusion of methotrexate and pingyangmycin in the treatment of patients with cesarean scar pregnancy(CSP)and its effect on vaginal bleeding.Methods Totally 102 pregnant women with CSP admitted to the Qinhuangdao Military Hospital from May 2018 to January 2020 were selected and randomly divided into the observation group and the control group,51 cases in each group.The patients in the two groups were treated with Methotrexate for Injection,on this basis,the patients in the observation group were treated with Pingyangmycin Hydrochloride for Injection,all the patients were administrated by bilateral uterine artery infusion for one week with once a day.Results The total effective rate of the observation group was 92.16%,which was significantly higher than 76.47%of the control group(P<0.05).The level ofβ-human chorionic gonadotropin(β-hCG)in the observation group was significantly lower than that in the control group on the first,third,sixth and twelfth day after treatment(P<0.05).During the treatment,the amount of vaginal bleeding in the observation group was significantly less than that in the control group,and the bleeding stop time in the observation group was significantly shorter than that in the control group(P<0.05).During the follow-up period,the gestational sac disappearance time,β-h CG normalization time and menstrual normalization time in the observation group were significantly shorter than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(13.73%vs.9.80%,P=0.290>0.05).Conclusion Bilateral uterine artery infusion of methotrexate and pingyangmycin in the treatment of patients with CSP can rapidly improve the level ofβ-h CG,reduce vaginal bleeding and improve the prognosis.