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Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods |
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| Authors: | Sala G Maspotch S Iturriaga H Blanco M Cerda V |
| Affiliation: | a Department of Chemistry, Analytical Chemistry Laboratory, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain b Department of Chemistry, Universitat Illes Balears, Palma de Mallorca, Spain |
| Abstract: | This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared. |
| Keywords: | Multicomponent analysis acetylsalicylic acid acetaminophen caffeine analgesic analysis UV spectrophotometry. |
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