动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性

目的 探讨动态增强磁共振成像（DCE-MRI）量化评估胰腺灌注的可行性。方法 将68名健康志愿者分为青年组、中年组和老年组。对所有志愿者均行DCE-MRI,将数据传至Research-DCEMRI Tool诊断分析工作站,计算胰腺灌注的定量参数：容积转运常数（K^trans）、间质-血浆速率常数（K_ep）、间质容积（V_e）和血浆容积（V_p）。采用两独立样本t检验和单因素方差分析评估不同性别、年龄组和胰腺部位的灌注参数。结果 不同性别志愿者K^trans、K_ep、V_e和V_p差异均无统计学意义（P均>0.05）；老年组V_e高于青年组和中年组（P=0.036、0.001）；胰头区V_p高于胰体部和胰尾部（P=0.011、0.023）。结论 DCE-MRI可无创、较稳定、定量评估胰腺灌注情况。胰腺DCE-MRI定量灌注参数不随性别差异而不同,但随年龄和胰腺部位的不同而有差异。

Feasibility of quantitative assessment of pancreatic perfusion with dynamic contrast-enhanced MRI in healthy volunteers

Objective To explore the feasibility of quantitative assessment of pancreatic perfusion using dynamic contrast-enhanced MRI (DCE-MRI). Methods Totally 68 healthy volunteers were divided into youth, middle and old groups according to ages. All volunteers underwent pancreas DCE-MRI examination. Images were transmitted to Research-DCE MRI Tool workstation to calculate the quantitative parameters, including volume transfer constant (K^trans), interstitium-to-plasma rate constant (K_ep), interstitial volume (V_e) and plasma volume (V_p). Independent sample t test and one-way ANOVA test were used to evaluate the differences of pancreatic perfusion. Results There were no significant differences of K^trans, K_ep, V_e and V_p between male and female; V_e in old group was higher than that in youth and middle groups (P=0.036, 0.001); V_p of pancreatic head was higher than that of pancreatic body and tail (P=0.011, 0.023). Conclusion DCE-MRI can be applied to provide a reliable quantitative assessment of pancreatic perfusion noninvasively. The parameters of DCE-MRI of pancreatic perfusion are independent of gender but vary with age and pancreatic sites.