Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer) |
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| Authors: | Kiyoshi Yoshimura Kelly Olino Barish H. Edil Richard D. Schulick Masaaki Oka |
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| Affiliation: | 1. Department of Surgery II, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
2. Department of Surgery, Johns Hopkins University School of Medicine, 1650 Orleans Street, The Bunting Blaustein Cancer Research Building, Room 442, Baltimore, MD, 21231, USA
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| Abstract: | Current treatment modalities of surgical resection and chemotherapy against cancers have improved survival. However, mortality from tumor recurrence remains high. Immunotherapy and gene therapy are potential additions to the treatment arsenal in the care of cancer patients. These novel therapeutic approaches need further investigation in in vitro and in vivo models as they are developed for potential use in humans. Here we reviewed immunotherapies and gene therapies that included clinical trials against cancers (mainly focusing on pancreatic cancer) suggesting the strong possibility of using these novel approaches. |
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