| 无色素性恶性黑色素瘤HMB45和 S-100蛋白的表达 |
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| 引用本文： | 唐四元,周建华,蒋海鹰,颜亚晖,傅春燕. 无色素性恶性黑色素瘤HMB45和 S-100蛋白的表达[J]. 实用预防医学, 2003, 10(2): 144-145 |
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| 作者姓名： | 唐四元 周建华 蒋海鹰 颜亚晖 傅春燕 |
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| 作者单位： | 中南大学湘雅医学院,中国湖南,长沙,410078 |
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| 摘 要： | 目的：探讨无色素性恶性黑色素瘤中HMB45和S--100的表达及其意义。方法：应用HMB45，S--100，Vimentin,NSE,Keratin,LCA,HHF45系列抗体对31例无色素性恶性黑色素瘤进行SP法免疫组织化学方法检测和分析。结果：3l例瘤组织中HMB45阳性率96．8％(30／31)，S--100 80．6％(25／31)，Vimentinl00％(31／31)，而NSE，Keratin，LCA，HHF35均呈阴性。结论：无色素型恶性黑色素瘤组织中HMB45阳性表达率高，免疫标记有助于无色素性病例的确诊和鉴别诊断。
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| 关 键 词： | 黑色素瘤 免疫组化 诊断 |
| 文章编号： | 1006-3110(2003)02-0144-02 |
| 修稿时间： | 2002-12-02 |
The Expressions of HMB45 ,S-100 in Amelanotic Malignant Melanoma |
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| Tang Siyuan,Zhou Jianhua,Jiang Haiying,et al.. The Expressions of HMB45 ,S-100 in Amelanotic Malignant Melanoma[J]. Practical Preventive Medicine, 2003, 10(2): 144-145 |
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| Authors: | Tang Siyuan Zhou Jianhua Jiang Haiying et al. |
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| Abstract: | Objective To explore the expressions of HMB45 and S-100 as well as their significances in amelanotic malignant melanoma (AMM). Methods A series of antibodies including HMB45, S-100, Vimentin, NSE,Keratin, LCA, HHF35 were used on paraffin sections in 31 cases of AMM by SP immunohistochemical methods. Result Positive rates of HMB45, S-100, Vimentin staining were 96.8%(30/31), 80.6%(25/31), 100%(31/31) respectively, while none showed immunoreactivity with NSE, Keratin, LCA, HHF35. Conclusion HMB45 may be a specific marker for AMM. Inmunohistochemistry is a good help for its confirmed diagnosis and differentiation. |
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| Keywords: | Melanoma Immunohistochemistry Diagnosis |
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