The production of antibody to bovine serum albumin in unresponsive (Sobey) mice

Mice (Sobey) bred to select lack of antibody production against bovine serum albumin have been examined for their responsiveness over a wide range of antigen doses. With low doses of antigen both Sobey mice and an outbred line of Swiss White mice produce similar amounts of antibody. Antigen in amounts greater than 500 μg produce tolerance more effectively in Sobey mice and this is the reason for their unresponsiveness at high antigen dose levels.